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Updated: Jun 9, 2025

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探索药物发现中化合物选择中药学向中介低等离子体暴露对化合物选择的影响 - 一种建模方法

Min Xu1, Duxin Sun2, Guohua An3

  • 1Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave, Iowa City, Iowa, 52242, USA.

The AAPS journal
|October 29, 2024
PubMed
概括

低药物开发成功可能源于目标介导的低血暴露. 传统的药理动力学标准可能会错误地选择化合物,忽视具有高标结合但低血度的候选物.

关键词:
TMDDDD TMDDDD 这是一个很大的问题.化合物的选择 化合物的选择最小的PBPK模型制药计量模型的制药计量模型.小分子药物开发小分子药物开发目标介导的低等离子体暴露.

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