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染色共价有机框架,使生物体内化学断层扫描成为可能

Song Wang¹, Yangyang Han¹, Vaishnavi Amarr Reddy²

¹Disruptive & Sustainable Technologies for Agricultural Precision, Singapore-MIT Alliance for Research and Technology Centre, Singapore, 138602, Singapore.

Nature communications

|October 29, 2024

概括

研究人员在丝纤维素微针中开发了新的染色共价有机框架 (COF). 这些传感器在3D中绘制植物血管液的pH值,通过智能手机技术检测干旱压力.

科学领域:

材料科学材料科学材料科学
植物生物学植物生物学
化学传感器化学传感器

背景情况:

染色共价有机框架 (COFs) 为生物界面传感提供了潜力.
化学断层扫描或3D化学映射对于理解复杂的生物系统至关重要.
生物相容矩阵对于将传感器集成到生物系统中至关重要.

研究的目的:

开发一种基于COF的传感器,用于in-vivo植物化学断层扫描.
使用丝纤维素 (SF) 微针来探测植物血管.
通过血管液的化来检测干旱压力.

主要方法:

将可调节pKa的Schiff基COF集成到SF微针中.
用COF (120-950 nm) 涂覆SF微针.
利用智能手机技术进行3D in-vivo化学渐变映射.

主要成果:

展示了COF集成的SF微针用于植物血管探测.
成功感知了血管液化作为干旱压力生物标志物.
实现了植物组织的3D in-vivo化学断层扫描.

结论:

在SF微针中使用的色彩COF传感器,可以对植物中的化学梯度进行3D映射.
这项技术为复杂生物环境的in-vivo化学断层扫描提供了一个新的工具.
开发的传感器为以前无法访问的系统提供了多维化学绘制的途径.

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