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Updated: Jun 9, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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类型IV-A1和IV-A3介导的CRISPR干扰的结构变化

R Čepaitė1, N Klein2, A Mikšys1,3

  • 1LSC-EMBL Partnership Institute for Genome Editing Technologies, Life Sciences Center, Vilnius University, Vilnius, Lithuania.

Nature communications
|October 29, 2024
PubMed
概括

第IV-A型CRISPR-Cas系统使用独特的DNA干扰途径,独立于核酶. 结构研究揭示了这些系统如何结合DNA点,并为基因调节招募效应螺旋酶.

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