高血压和全球DNA甲基化:印度旁遮普省农村地区的基于人口的研究
Anshika Kaushik1, Debashis Bhattacharjee1, Vineet Chaudhary1
1Laboratory of Molecular and Biochemical Anthropology, Department of Anthropology, University of Delhi, Delhi, 110007, India.
Scientific reports
|October 29, 2024
概括
高血压与较低的全球DNA甲基化有关,增加风险. 叶酸可能有助于改善血压控制的高血压患者的甲基化.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 营养生物化学 营养生物化学
- 公共卫生 公共卫生
背景情况:
- 高血压是全球主要的健康问题,死亡率很高.
- 基因与环境的相互作用和微量营养素的摄入影响高血压.
- 了解表观遗传修饰,如高血压中DNA甲基化,至关重要.
研究的目的:
- 调查全球DNA甲基化 (5mC) 和高血压之间的关联.
- 探索微量营养素 (叶酸,维生素B12,homocysteine) 在这种关系中的作用.
- 为了检查高血压患者的甲基化差异,控制和不受控制的血压.
主要方法:
- 在印度旁遮普省农村地区,对900名年龄在30-75岁的参与者 (450例,450例对照) 进行了横截面研究.
- 使用ELISA在外围血液白细胞中评估全球DNA甲基化 (5mC).
- 通过化学发光测量血清叶酸,维生素B12和同类半氨酸水平.
主要成果:
- 与高血压患者 (0.72) 相比,高血压患者的全球DNA甲基化水平显著降低 (0.65).
- 较低的DNA甲基化 (第一四分位数) 与高血压风险增加1.67倍有关.
- 服用药物控制血压的高血压患者的甲基化水平比不控制血压的患者高.
结论:
- 这种人群的高血压与全球DNA低甲基化有关.
- 叶酸充足可能在治疗高血压患者的DNA甲基化改善中发挥作用.
- 低甲基化可能表明年轻的高血压患者的生物衰老加速.
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