Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

227
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
227
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

486
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
486

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Short-term effects of exercise therapy on pulmonary function and exercise tolerance in patients with mild to moderate adolescent idiopathic scoliosis: a meta-analysis of randomized controlled trial.

Frontiers in sports and active living·2026
Same author

Peripheral and central vestibular neuromodulation improve postural control in adolescent idiopathic scoliosis: a randomized, sham-controlled, multi-arm intervention study.

Journal of neuroengineering and rehabilitation·2026
Same author

Integrative multi-omics analysis identifies endocrine-disrupting chemical-related molecular mechanisms in migraine.

The journal of headache and pain·2026
Same author

PancDS in Real-World Practice: A Prospective Multicenter Validation of a Clinical Decision-Support System Bridging Experience Gaps in Pancreatic Lesion Diagnosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Neuromuscular control mechanism during posture-cognition dual task in mild cognitive impairment: a concurrent fNIRS-sEMG-COP study.

GeroScience·2026
Same author

PPP2R2C confers radioresistance in nasopharyngeal carcinoma by suppressing ferroptosis via RPS27L stabilization.

Cell death & disease·2026

相关实验视频

Updated: Jun 9, 2025

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes
08:42

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Published on: July 18, 2008

16.0K

帕金森病的可用药物标:基于转录学的门德尔随机化研究.

Qiong Lyu1,2,3, Rong Chen4, Zhengang Qiu5,6

  • 1Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.

Scientific reports
|October 29, 2024
PubMed
概括

新的研究确定了P2RX7和RNASET2作为帕金森病 (PD) 的潜在治疗点. 这些基因在PD中表达变化,可能提供超出症状管理的治疗新途径.

关键词:
微分表达式分析 微分表达式分析门德尔的随机化帕金森病是帕金森氏症的一种疾病.基于统计数据的总结 MR.有针对性的治疗.

更多相关视频

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.5K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.4K

相关实验视频

Last Updated: Jun 9, 2025

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes
08:42

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Published on: July 18, 2008

16.0K
Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.5K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.4K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学 是一个
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 帕金森病 (PD) 是一种常见的神经退行性疾病.
  • 目前的PD治疗方法可以控制症状,但不能阻止疾病的进展,并且可能导致副作用.
  • 新的可用药物的治疗目标对于有效的PD干预至关重要.

研究的目的:

  • 为了确定与帕金森病相关的新型可药基因.
  • 用遗传分析研究基因表达和PD之间的因果关系.
  • 探索已识别的目标在PD治疗开发的潜力.

主要方法:

  • 从PD中黑色物质地区的六个GEO转录组数据集的分析.
  • 基于孟德尔随机化 (MR) 和总结统计的MR (SMR) 分析,使用大脑和血液eQTL数据.
  • 候选基因表达与疾病阶段相关的验证,使用数据集GSE49036.
  • 全现象MR分析,以评估候选基因对其他复杂特征的影响.

主要成果:

  • 鉴定了PD中313个差异表达,潜在的向基因.
  • 通过MR和SMR分析证实P2RX7和RNASET2是可行的PD治疗点.
  • 随着PD进展 (Braak阶段),P2RX7和RNASET2的表达增加.
  • 全现象MR分析显示了针对RNASET2.2的额外影响.

结论:

  • P2RX7和RNASET2代表了对帕金森病有前途的可用药物标.
  • 遗传证据支持针对这些基因的治疗潜力.
  • 这项研究为开发新的PD治疗方法提供了基础.