胆结石中的长期体重模式和身体活动
Hyun Jung Kim1,2, Tae Uk Kang3, Min Jung Kim4
1Cochrane Korea, Korea University College of Medicine, Seoul, Korea.
Scientific reports
|October 29, 2024
概括
显著的体重变化,包括体重减轻或增加,会增加胆结石风险. 定期体育活动可以减轻这些风险,特别是在经历大量体重波动的个体中.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 胆结石受到肥胖,快速减肥和不活动的影响.
- 长期体重模式的影响和身体活动在胆结石风险中的作用需要进一步的人口水平研究.
研究的目的:
- 调查长期体重模式 (增加,减轻,骑自行车) 和身体活动与胆结石风险之间的关联.
- 分析这些关联如何因性别和年龄而异.
主要方法:
- 从韩国健康数据库中分析了5,062,154名受试者的大量队列 (2002-2018).
- 危险比率 (HRs) 为体重模式和体育活动计算,并对BMI和糖尿病等共变量进行调整.
- 根据性别和年龄 (<45岁和≥45岁) 进行了子组分析.
主要成果:
- 所有体重变化组都显示胆结石风险增加:体重减轻>20% (HR 1.32),体重增加>20% (HR 1.13),体重循环 (HR 1.04),体重增加5-20% (HR 1.03),体重减轻5-20% (HR 1.02).
- 风险因BMI类别,性别和年龄而异,男性和老年人更容易受到减肥风险的影响,女性和年轻人更容易受到体重增加风险的影响.
- 定期体育活动显著降低了体重变化的人的胆结石风险,特别是那些体重增加>20%的人 (61%的减肥).
结论:
- 体重增加,减肥和骑自行车与增加胆结石风险有关.
- 定期体育活动可以有效地减轻与体重波动相关的胆结石风险.
- 体重模式对胆结石风险的影响是由性别和年龄调节的.
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