数字AVATAR治疗精神病中令人痛苦的声音:第2/3期AVATAR2试验
Philippa A Garety1,2, Clementine J Edwards3,4, Hassan Jafari5
1Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. Philippa.Garety@kcl.ac.uk.
Nature medicine
|October 29, 2024
概括
阿凡达疗法是令人痛苦的声音的数字化体现,在16周后,精神病症状的痛苦显著改善. 阿凡达扩展 (AV-EXT) 协议显示了临床上显著的变化,需要进一步调查.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 数字治疗学数字治疗学
背景情况:
- 痛苦的声音是精神病的首要症状,目前的治疗方法提供了低于最佳的缓解.
- 迫切需要新的有效干预措施来管理精神病患者的听觉幻觉.
研究的目的:
- 评估两种AVATAR治疗方案 (AVATAR-Brief和AVATAR-Extended) 与通常治疗 (TAU) 相结合的有效性,与TAU单独相比,在减少与声音相关的痛苦方面.
- 评估AVATAR治疗对患有精神病的参与者的语音严重性和频率的影响.
主要方法:
- 一个随机的2/3期试验,涉及345名患有精神病的参与者.
- 参与者接受了AVATAR-Brief (AV-BRF) + TAU,AVATAR-Extended (AV-EXT) + TAU,或仅使用TAU.
- 主要结局是16周和28周测量语音相关的痛苦;次要结局包括语音严重程度和频率.
主要成果:
- 与TAU相比,AV-BRF和AV-EXT在16周显著降低了与声音相关的痛苦 (AV-BRF:P=0.035;AV-EXT:P=0.029).
- 对于任何AVATAR协议来说,在28周后,痛苦的改善都没有持续.
- AV-EXT 显示出临床上显著的变化,并且在两个时间点使用 AV-EXT 减少了语音频率. 没有报告任何严重的不良事件.
结论:
- 阿凡达疗法,特别是阿凡达扩展方案,在缓解精神病中令人痛苦的声音方面表现有前途,特别是在短期内.
- 该AVATAR-Extended协议符合临床意义的标准,建议它作为未来研究和临床应用的首选方法.
- 需要进一步的研究,以了解AVATAR疗法对精神病中令人痛苦的声音的长期疗效和机制.
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