相关实验视频

Updated: Jun 9, 2025

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

选择性报告偏差对中风试验的影响:证据综合的潜在妥协 - 一项横截面研究

Xinyao Wang^1,2,3, Youlin Long^2,3, Na Zhang^2,3

¹General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

BMC medical research methodology

|October 29, 2024

概括

对结果的选择性报告在急性缺血性中风 (AIS) 随机对照试验 (RCT) 中很常见,影响了超过60%的结果. 这种偏见,特别是结果的加法,与积极的结果和在影响较低的期刊上发表相关.

科学领域:

临床试验临床试验
医学研究诚信医学研究诚信
神经学神经学

背景情况:

在随机对照试验 (RCT) 中准确报告结果对于可靠的结果解释至关重要.
对结果的选择性报告有利于预期的结果仍然是医学研究中经常出现的问题.
本研究侧重于急性缺血性中风 (AIS) RCT,以调查选择性报告的患病率和影响.

研究的目的:

确定在急性缺血性中风 (AIS) 随机对照试验 (RCT) 中选择性结果报告的流行率.
在AIS RCT中识别与选择性结果报告相关的因素.
评估选择性报告对AIS研究中观察到的干预效应的影响.

主要方法:

在MEDLINE,Embase和Cochrane图书馆系统搜索2020-2022年间发表的干预性AIS RCT.
纳入标准要求报告国际临床试验注册平台 (ICTRP) 主要注册表号,以便与出版物进行比较.
用贝叶斯的多层次物流回归来分析有助于选择性报告的因素.

主要成果:

在159个已识别的AIS RCT中,包括82个,报告了819个结果.
在72个RCT (87.8%) 和497个结局 (60.7%) 中观察到选择性报告.
遗漏类型的选择性报告与负面结果相关 (OR:7.39),而添加类型的选择性报告与积极结果相关 (OR:2.07) 和非顶级四分位数期刊的出版 (OR:2.48).

结论:

对结果的选择性报告在注册的干预AIS RCT中仍然是一个重大问题.
需要进一步评估,以了解选择性报告偏差对AIS RCT和随后的系统审查中报告的积极结果的影响.

关键词:

急性缺血性中风是一次急性缺血性中风.证据综合研究随机对照试验是随机对照试验.选择性报告偏见是一种选择性报告偏见.

更多相关视频

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Published on: May 5, 2023

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

相关概念视频

Bias

Bias

Bias refers to any tendency that prevents a question from being considered unprejudiced. In research, bias occurs when one outcome or answer is selected or encouraged over others in sampling or testing. Bias can occur during any research phase, including study design, data collection, analysis, and publication.
In statistics, a sampling bias is created when a sample is collected from a population, and some members of the population are not as likely to be chosen as others (remember, each member...

Bias in Epidemiological Studies

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:

Blind Procedures

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...

Blinding

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.