制定性别衡量标准并检查其与心血管疾病发病率的关联:一项为期28年的前性队列研究
Mahée Gilbert-Ouimet1,2,3, Azita Zahiriharsini4,5, Caty Blanchette6
1Health Sciences Department, Université du Québec À Rimouski Campus de Lévis, Lévis, Québec, G6V 0A6, Canada. mahee_gilbert-ouimet@uqar.ca.
BMC medicine
|October 29, 2024
概括
在传统的女性特征上得分较高的男性患心血管疾病 (CVD) 的风险增加了50%. 这项研究强调了在心血管疾病研究和预防策略中考虑性别的重要性,该战略适用于所有性别.
科学领域:
- 心脏病学 心脏病学
- 社会学 社会学 社会学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 了解超越生物性别的社会文化性别因素,对于解决健康不平等至关重要.
- 之前的研究还没有将全面的性别措施完全纳入心血管疾病风险评估中.
研究的目的:
- 制定一个包含四个维度的性别措施.
- 在一项队列研究中调查这一性别测量与心血管疾病发病率之间的关联.
- 检查性别与心血管疾病风险之间的关系中的潜在基于性别的差异.
主要方法:
- 在北克 (1991-1993年) 招募了9188名白领工人的队列,对心血管疾病发病率进行了28年的随访.
- 数据包括对心血管疾病病例的自我管理问卷和医疗行政记录.
- 考克斯比例模型被用于计算危险比率 (HR) 和95%置信区间 (CI),按性别分层.
主要成果:
- 性别和性别指标显示部分独立性,性别分数分布在性别之间有所变化.
- 与最低的三分之一相比,最高性别分数三分之一 (更传统的女性特征) 的男性患心血管疾病风险增加了50% (HR=1.50).
- 在对心血管疾病风险因素进行调整后,男性的这种关联仍然存在 (HR=1.42),而女性没有发现任何显著的关联 (HR=0.79).
结论:
- 传统上女性性特征的较高水平与男性心血管疾病风险增加有关.
- 在具有相似性别特征的女性中没有观察到心血管疾病风险增加.
- 整合性别和性别措施对于推进心血管健康研究和改善预防策略至关重要.
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