在表观遗传性酒精风险评分和血压之间进行关联分析
Helena Bui1,2, Amena Keshawarz1,2, Mengyao Wang3
1Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Clinical epigenetics
|October 29, 2024
概括
饮酒表观遗传风险评分 (ERS) 与高血压 (BP) 和高血压风险有关. 这一分数可以帮助评估心血管风险,当自我报告的酒精摄入量是不可靠的.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 心血管疾病流行病学
- 行为科学 行为科学
背景情况:
- 全表观基因组相关性研究 (EWAS) 将DNA甲基化位点 (CpG) 与酒精消费联系起来.
- 酒精摄入量是心血管疾病的重要生活方式风险因素.
- 这项研究调查了饮酒表观遗传风险评分 (ERS) 和血压 (BP) 特征之间的关联.
研究的目的:
- 为了测试一种假设,即酒精消费表观遗传风险评分 (ERS) 与血压 (BP) 特征有关.
- 评估ERS在评估心血管风险方面的临床实用性.
- 探索ERS和高血压 (HTN) 之间的关系.
主要方法:
- 使用先前报告的144种与酒精相关的CpG的表观遗传特征实施了ERS.
- 对欧洲血统的参与者进行了元分析.
- 与血压特征 (心血压,腹血压) 和HTN的关联在弗雷明汉心脏研究 (FHS) 和八个独立的外部队列中进行了检查.
主要成果:
- 在ERS中增加1个单位与每天消耗的约11个额外的酒精饮料相关.
- 在FHS的横截面分析显示,ERS与更高的SBP,DBP和增加HTN的几率有关.
- 在外部队列中的元分析证实了ERS与更高的SBP和DBP相关,但不是HTN. 纵向分析显示,与BP变化或事件HTN无关.
结论:
- 酒精消费ESR证明了对评估与心血管风险相关的生活方式因素的潜在临床实用性.
- 当自我报告的酒精消费数据不可用或不可靠时,ERS可能特别有价值.
- 这种表观遗传标记为心血管风险评估提供了一个客观的衡量标准.
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