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在住院抗凝药患者肌肉内注射后的出血并发症:一项回顾性观察性比较研究

Marina Davidov¹, Ronen Loebstein^2,3, Hagith Yonath^1,3

¹Department of Internal Medicine A, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Thrombosis journal

|October 29, 2024

概括

肌内注射导致的出血并发症在接受抗凝药治疗的住院患者中很少见. 该研究发现,风险可能不高于未服用抗凝血剂的患者,只有两个病例被确定.

科学领域:

临床医学临床医学
药理学药理学是指药理学的学科.
患者安全患者安全

背景情况:

肌内注射 (IM) 通常具有较低的出血并发症风险 (0.06%).
在接受抗凝血治疗的住院患者中,IM注射的安全性存在有限的数据.
这项研究解决了关于注射部位出血在抗凝血患者的知识差距.

研究的目的:

为了确定IM注射部位出血并发症的发生率.
为了比较抗凝血剂与非抗凝血剂住院患者的出血风险.
在一个脆弱的患者群体中评估IM注射的安全性.

主要方法:

成年住院患者接受IM注射的回顾性比较研究 (2009-2019).
利用ICD-9代码和间接指标 (血红蛋白下降,酶增加,输血) 来识别潜在的出血.
使用自然语言处理和手动图表审查验证了注射部位出血.

主要成果:

分析了71,710名患者和236,406个内脏注射.
在8,189名患者 (40,819注射) 中存在抗凝固作用.
两例真正注射部位出血的病例得到证实,这两例都发生在服用抗凝固药的组中 (发病率为0.02%).

结论:

在接受抗凝固药物治疗的住院患者中,内脏注射部位出血并发症很少见.
在抗凝血和非抗凝血患者之间,从内脏注射出血的风险似乎是可比的.
当适当的监测到位时,可以认为IM注射在抗凝血患者中是安全的.

关键词:

药物不良事件是药物不良事件.这是一种抗凝血药物.流血出血流血出血药物相互作用药物相互作用肌肉内注射肌肉内注射

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