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Updated: Jun 9, 2025

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
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用PDGF-BB治疗的人类肺动脉光滑肌细胞的代谢变化

Meng-Jie Zhang1, Jie-Jian Kou2, Hong-Da Zhang3

  • 1School of Pharmacy, Henan University, Kaifeng, China.

Animal models and experimental medicine
|October 29, 2024
PubMed
概括

肺动脉光滑肌细胞 (PASMC) 的代谢变化与肺动脉高血压有关. 这项研究揭示了PASMC表型变化期间的显著代谢变化,特别是酸盐代谢,可能导致血管重塑.

关键词:
代谢生物组的代谢生物组肺动脉高血压 肺动脉高血压皮鲁酸盐的新陈代谢血管改造 血管改造 血管改造

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Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
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