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前置手术与前置同时化学放射治疗作为下甲状腺细胞癌的主要方式:系统性审查和元分析

Tsung-You Tsai¹, Wing-Keen Yap², Ting-Hao Wang^1,3

¹Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

|October 29, 2024

概括

前置手术提供更好的整体生存率 (OS) 和无病生存率 (DFS) 的下支柱状细胞癌 (HPSCC) 与前置化疗和放射治疗相比. 这一元分析突出了外科手术的重点.

科学领域:

头部和部瘤学头部和部瘤学
手术瘤学手术瘤学
辐射瘤学辐射瘤学

背景情况:

下状状细胞癌 (HPSCC) 的管理在头部和部瘤学中提出了重大挑战.
治疗决策显著影响患者的生存结果.

研究的目的:

为了比较HPSCC的前期手术和前期并发化疗和放射治疗之间的生存结果.
评估HPSCC不同主要治疗方式的疗效.

主要方法:

按照PRISMA指南进行系统审查和元分析.
在PubMed,EMBASE和Cochrane图书馆的文献搜索到2023年1月.
包括未接受诱导化疗的HPSCC患者的研究,比较前期手术与并发化疗,并报告总生存率 (OS) 和无病生存率 (DFS).

主要成果:

八项研究 (1619名患者) 显示,与并发化疗或放射治疗相比,前置手术显著改善了OS (aHR 0.66) 和DFS (aHR 0.75).
对高级HPSCC (III-IV阶段) 的亚组分析显示,前期手术维持了优越的OS (aHR 0.65).
专用全喉切除术和全/部分喉切除术两小组都在进行前置手术时表现出更好的生存状况.

结论:

前置手术与HPSCC患者的优越整体存活率和无病存活率有关.
临床医生在选择并发化学放射治疗作为HPSCC的首要治疗时,应考虑降低生存结果的可能性.

关键词:

在CRT中,CRT可以在CRT中使用.在HPSCCCC中使用.化学疗法或放射治疗鼻下的癌症是一种癌症.状细胞癌 (SCLC) 是一种状细胞癌.这是一次前期的手术手术.

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