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暴露于热量会通过肠道微生物群衍生代谢物促进肉症
Yi-Fan Guo1, Zhe-Yu Liu1, Min Zhou1
1Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Aging cell
|October 29, 2024
概括
长期暴露于热量会通过改变肠道细菌和增加homocitrulline而导致肌肉损失和衰弱. 用Nrf2激活剂 (Oltipraz) 补充可以预防热引起的肉症.
科学领域:
- 环境健康 环境健康
- 肌肉生理学 肌肉生理学
- 微生物组研究 微生物组研究
背景情况:
- 全球气温上升带来了重大的健康风险.
- 暴露于热量对萨尔科佩尼亚发展的影响尚不清楚.
研究的目的:
- 为了研究慢性热暴露对骨肌肉健康的影响.
- 阐明连接热暴露,肠道微生物群和肉类的机制.
主要方法:
- 对微生物群组成进行16S核糖体DNA分析.
- 液体染色学-质谱学 (LC-MS) 用于代谢组分析.
- 在无菌小鼠中进行微生物群移植研究.
主要成果:
- 长期暴露于热量导致骨肌体积损失,强度下降和功能下降.
- 暴露于热量会改变肠道微生物群的组成,并增加血清中同位素水平.
- 热量改变的微生物群的移植加剧了肌肉功能障碍.
- 人类素被确定为一个关键的调解者,导致线粒体功能障碍和肌细胞中的铁亡.
- 作为 Nrf2 激活剂的 Oltipraz 改善了热引起的肌肉缩和功能障碍.
结论:
- 长期暴露于热量会对骨肌肉功能产生不利影响,导致肉症.
- 肠道微生物群的变化和高水平的homocitrulline在热引起的肌肉功能障碍中起着至关重要的作用.
- Nrf2激活为缓解与热相关的肉症提供了潜在的治疗策略.
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