乳化剂稳定助剂乳液的体外消化行为影响着黄酸的生物可访问性
Yanping Lin1,2, David Julian McClements3, Junlin Zhang1,2
1Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, China.
Journal of the science of food and agriculture
|October 29, 2024
概括
辅助剂乳液增强了黄类生物可用性. 在80 (TW80) 之间,由于滴粒尺寸较小和消化能力更好,改善了奎尔素,凯姆菲罗尔和阿皮基宁的吸收,超过了乳清蛋白分离物 (WPI) 或八酸酸无水化物 (OSA) 修饰的粉 (MS).
科学领域:
- 食品科学 食品科学 食品科学
- 营养科学 营养科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 来自水果和蔬菜的黄酸具有健康益处,但其生物可用性较差.
- 辅助剂乳液是一种有前途的策略,可以改善黄酸吸收.
- 乳化剂类型和黄胺结构显著影响黄胺生物可访问性.
研究的目的:
- 调查辅助剂乳液界面特性如何影响弗拉类药物的体外胃肠道命运.
- 为了比较不同乳化剂 (Tween 80,乳清蛋白分离物,OSA修饰粉) 在增强黄类生物可访问性方面的疗效.
- 为了将黄类生物可访问性与它们的分子性质和乳液特征相关联.
主要方法:
- 使用了INFOGEST的体外消化模型.
- 使用Tween 80 (TW80),乳清蛋白分离物 (WPI) 和用八酸酸无水化物 (OSA) 修饰的粉 (MS) 制备的辅助剂乳液.
- 评估了乳液界面特性,滴滴大小稳定性,体外消化性和黄类物质 (quercetin,kaempferol,apigenin) 的生物可访问性.
主要成果:
- 与WPI和MS相比,Tween 80 (TW80) 降低了界面张力,形成了较小,更稳定的油滴.
- TW80-乳液显示由于增加脂质表面积增加脂酶活性,增强了消化能力.
- 黄类生物可访问性按照以下顺序进行:TW80 (2545%) >WPI (1429%) ≈MS (1525%),受乳化剂和黄类结构的影响.
结论:
- 乳化剂的选择极大地影响了辅助剂的乳液性能和黄类生物可访问性.
- Tween 80是一种优质的乳化剂,可增强奎尔丁,凯姆菲罗尔和阿皮金因的生物可用性.
- 这些发现指导了先进的辅助剂乳液的合理设计,以改善营养药物输送.
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