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STAT3/p-STAT3表达与非小细胞肺癌的临床病理特征和预后相关

Jili Li¹, Yingying Zhu², Jianyue Peng¹

¹West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.

Histology and histopathology

|October 29, 2024

概括

信号传感器和转录因子3 (STAT3) 和其酸化形式 (p-STAT3) 的激活剂在非小细胞肺癌中被上调. p-STAT3与年龄和病理相关,表明其作为生物标志物的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

信号传感器和转录因子3 (STAT3) 的激活器与瘤发生有关.
在非小细胞肺癌 (NSCLC) 中,STAT3/p-STAT3 的预后意义仍未得到充分研究.

研究的目的:

研究NSCLC中STAT3和化STAT3 (p-STAT3) 的预后价值.
确定STAT3/p-STAT3表达与临床特征和患者存活率的关联.

主要方法:

免疫组织化学用于评估239个NSCLC组织和71个正常肺组织中的STAT3/p-STAT3表达.
统计分析包括皮尔森的千平方测试和卡普兰-梅尔生存分析.

主要成果:

与正常组织相比,NSCLC组织中的STAT3/p-STAT3显著上调 (p<0.001).
患者的p-STAT3表达与患者年龄 (p=0.046) 和病理类型 (p=0.037) 相相关.
在60岁以上的患者中,STAT3阳性与生存率较差有关 (p=0.043),但在多变量分析中并不是独立的预后因素 (p=0.083).

结论:

在NSCLC中,STAT3/p-STAT3受到上调,可以作为潜在的生物标志物.
需要进一步的研究,以充分阐明STAT3/p-STAT3在NSCLC预后中的作用.

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