在男性献血者体内自然存在的Anti-D,未解之
Ritika Basnotra1, Joseph Philip1, R S Mallhi1
1Department of Immunohematology and Blood Transfusion, Medical College, Bharati Vidyapeeth Deemed University, Pune Satara Road, 411043 Dhankawadi, Pune, Maharashtra India.
概括
常规的献血者查检测到一个意外的抗D抗体在一个男性捐献者. 这一案例凸显了间接库姆斯试验 (ICT) 在识别对输血安全潜在有害抗体方面的重要性.
科学领域:
- 输血医学 输血医学
- 免疫学 免疫学 免疫学
- 血液银行 血液银行
背景情况:
- 对红细胞抗体进行捐献血液的查对于患者的安全至关重要.
- 抗体的形成可以通过免疫反应,自然或被动地发生.
- 间接库姆斯测试 (ICT) 是血液储存中的标准程序.
研究的目的:
- 为了调查一个意想不到的积极的ICT结果在一个献血者.
- 识别特定抗体及其潜在来源.
- 强调ICT在供体查中的重要性.
主要方法:
- 关于捐献者血液样本的ABO Rh分组和ICT.
- 使用面板进行抗体查和鉴定.
- 捐赠者病史和进一步的实验室工作,以排除已知的免疫原因.
主要成果:
- 一名30岁的男性捐赠者测试了A Rh D阴性与阳性ICT (+2).
- 鉴定出抗D (IgG) 抗体的标位高达1:32.
- 在捐赠者的病史中没有发现Rh同免疫的明确来源.
结论:
- 捐赠者很可能拥有天然存在的抗D,可能是由于环境因素或与其他抗原的交叉反应.
- 这一案例强调了ICT在检测献血者意外抗体方面的关键作用.
- 当排除了潜在的与免疫接种的原因时,需要进行彻底的调查.
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