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在COVID-19住院28个月后持续残疾,前性队列研究

Bertrand Renaud^1,2,3, Richard Chocron^4,5,3, Guillaume Reverdito^5,6

¹Unité d'Explorations Fonctionnelles Respiratoires et du Sommeil, Hôpital Européen Georges-Pompidou, AP-HP, Paris, France.

ERJ open research

|October 29, 2024

概括

长期的COVID可能会导致持续的呼吸系统问题,但肺功能通常会在28个月内改善. 大多数患者康复,很少有人在COVID-19康复后表现出持续的肺损伤.

科学领域:

肺部病理学肺部病理学
传染性疾病传染性疾病
流行病学流行病学

背景情况:

有限的数据存在于急性COVID-19后的长期呼吸障碍.
了解COVID-19后的呼吸系统后果对于患者管理至关重要.

研究的目的:

调查急性COVID-19住院患者的长期呼吸系统结果.
评估出院后28个月内临床,功能和放射性变化.

主要方法:

住院COVID-19患者的前性观察队列研究.
数据收集包括临床,功能 (肺功能测试) 和放射性评估,长达28个月.
对268名具有完整病历的患者进行分析.

主要成果:

69%的住院患者活着出院;51.5%的人报告了持续的症状,如喘息和呼吸障碍.
随着时间的推移,肺功能,包括肺部对一氧化碳 (DLCO) 的扩散能力和肺部总容量 (TLC) 的改善.
大多数患者在28个月后表现出正常的肺功能和最小的放射性变化,其中有一例中度肺纤维化.

结论:

COVID-19幸存者在呼吸系统症状和肺功能显著改善,长达28个月.
持续的症状主要是喘息和呼吸障碍,但肺功能往往会正常化.
在没有先前肺部并发症的患者中,长期呼吸系统残疾并不常见.

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