通过孟德尔的随机化分析识别有氧保护性水果和蔬菜
Shenji Yang1, Zhikang Cao1, Huidong Liu2
1State Key Laboratory of Food Science and Resources, China-Canada Joint Lab of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang, China.
这项研究发现,摄入水果和蔬菜,特别是大,可以因果性地降低动脉样硬化风险因素,如LDL-C和CRP. 这些发现强调了FV摄入对心血管健康的重要性.
科学领域:
- 营养流行病学 营养流行病学
- 心血管疾病研究研究
- 遗传流行病学遗传流行病学
背景情况:
- 据认为,水果和蔬菜可以降低动脉样硬化 (AS) 风险,但具体的因果关系尚不清楚.
- 动脉样硬化是一种主要的心血管疾病,具有复杂的危险因素.
- 了解FV-AS关系对于公共卫生和饮食指南至关重要.
研究的目的:
- 调查28FV摄入量与动脉样硬化风险因素之间的因果关系.
- 应用门德尔随机化 (MR) 来推断FV消费和AS之间的因果关系.
- 为了确定具有显著的动脉保护作用的特定FV.
主要方法:
- 采用了两样本的孟德尔随机化 (MR) 分析.
- 使用了全基因组关联研究 (GWAS) 的数据,用于FVs,AS,LDL-C,TG和CRP.
- 进行了敏感性分析,包括异质性和质性评估.
主要成果:
- 总水果摄入量因果降低了LDL-C和CRP水平.
- 总蔬菜摄入量导致CRP水平降低.
- 白摄入量显示出与降低AS风险,降低LDL-C和TG的最强的因果关系;果和土豆与较低的TG有关;桃子/花蜜与较低的CRP有关.
结论:
- 这是第一个系统地检查FV与AS因果关系的MR研究.
- 研究结果支持各种FVs,特别是大的动脉动脉保护作用.
- 结果强调了个性化营养对AS预防的重要性.
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