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功能性消化不良的长期诺普拉桑和阿科提胺耐药患者部分表现出胰腺酶异常
Ken Nakamura1, Seiji Futagami1, Shuhei Agawa1
1Department of Gastroenterology, Nippon Medical School, Tokyo, JPN.
长期使用vonoprazan,一个与竞争的酸阻塞剂 (P-CAB),单独或与acotiamide一起改善功能性消化不良 (FD) 症状. 在两组治疗中,整体治疗疗效约为50%.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 功能性消化不良 (FD) 是一种常见的胃肠道疾病.
- 普拉赞是一种新的竞争性酸阻断剂 (P-CAB),在日本可用.
- 关于长期使用vonoprazan或其与acotiamide的联合治疗FD的数据有限.
研究的目的:
- 评估vonoprazan单一治疗与vonoprazan和acotiamide联合治疗在FD患者的长期疗效.
- 评估这些治疗对FD症状和胰腺酶水平的影响.
主要方法:
- 共有73名FD患者 (罗马III分类) 被纳入.
- 42名患者接受了vonoprazan单疗法; 31名患者接受了vonoprazan和acotiamide联合治疗24周.
- 测量了胰腺酶水平;根据症状改善,评估了整体治疗有效性 (OTE).
主要成果:
- 诺普拉赞单疗法和联合疗法都显著改善了FD症状.
- 在各组之间,OTE是相似的:单一疗法为42.9%,组合疗法为52%.
- 在改善和不改善的患者之间观察到胰腺酶异常的显著差异,特别是在组合治疗组.
结论:
- 长期的诺普拉桑单疗法和联合疗法有效地改善了FD症状.
- 两种方案的整体治疗疗效约为50%.
- 组合治疗可能有助于区分患有胰腺酶异常的FD患者.
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