与诺基诺相关的精神疾病:FDA不良事件报告系统数据库的药监测分析
Wen-Long Xie1, Meng-Lan Ge1, Dan Chen2
1Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in pharmacology
|October 29, 2024
概括
诺基诺抗生素可以引起精神病药物不良反应 (ADRs),包括情绪障碍和精神病. 风险因药物和患者年龄而异,需要谨慎的处方和特定年龄的策略.
科学领域:
- 药物监督 药物监督 药物监督
- 药品安全 药品安全
- 神经科学是一个神经科学.
背景情况:
- 诺基诺是具有已知的中枢神经系统 (CNS) 药物不良反应 (ADRs) 的广谱抗生素.
- 精神病的不良反应是与诺基诺使用相关的重大问题.
研究的目的:
- 分析与诺基诺相关的精神病性副作用.
- 为了确定与特定的精神病副作用相关的特定诺基诺隆药物.
- 为了研究精神病ADR风险的年龄相关差异.
主要方法:
- 使用FDA不良事件报告系统 (FAERS) 数据 (2004年第一季度 - 2023年第四季度) 的回顾性药监测研究.
- 使用报告几率比率 (ROR) 的不成比例分析.
- 使用监管活动医学词典 (MedDRA) 和标准化MedDRA查询 (SMQ) 的ADRs分类.
主要成果:
- 在84,777份诺基诺报告中,发现了超过27,000份精神病学ADR报告.
- 情绪障碍 (焦虑,抑郁,妄想) 是最常见的,其中一些导致自杀念头.
- 齐普罗夫洛克萨与抑郁症/自杀念头有关;莫西弗洛克萨与妄想有关. 年龄影响风险:年轻的成年人有更多的情感障碍,年长的成年人有更多的精神病/妄想.
结论:
- 诺基诺与各种精神病的不良反应有关,具有药物特异性.
- 诺基诺的处方需要谨慎,特别是在有精神病史的患者或老年人中.
- 特定于年龄的预防策略对于安全的诺基诺管理至关重要.
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