冠状动脉支架的拓优化,考虑到结构和血液动力学参数
Fatemeh Ahadi1, Mohammad Azadi1, Mojtaba Biglari1
1Faculty of Mechanical Engineering, Semnan University, Semnan, Iran.
Heliyon
|October 29, 2024
概括
这项研究优化了支架的几何结构,以改善血液流动,发现改进的设计减少了动脉中不利的血液动力学变化. 新的支架结构增强了冠状动脉疾病的治疗.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 医疗器械设计 医疗器械设计
背景情况:
- 血管内支架对于恢复阻塞动脉的动脉血流至关重要.
- 支架设计显著影响血液动力学参数和治疗成功.
- 几何结构会影响静脉壁切割应力.
研究的目的:
- 调查支架几何变量和结构特征对血液动力学参数的影响.
- 设计一个最佳的支架,并将其性能与冠状动脉商业支架进行比较.
- 讨论支架结构在治疗冠状动脉疾病中的重要性.
主要方法:
- 用于设计最佳支架结构的拓优化技术.
- 使用ANSYS软件对优化的支架进行数值验证.
- 使用增材制造 (3D打印) 制造优化的支架原型.
- 与使用ABAQUS,SolidWorks和ANSYS软件的现有商业支架进行比较.
主要成果:
- 优化的支架设计证明了对墙壁剪切应力分布的有效影响.
- 新设计可以改善墙壁剪切应力分布,减少不良的血液动力学变化.
- 10-7%的最小残留体积极限被确定为方形板样本的最佳值.
结论:
- 支架几何学极大地影响了血液动力学参数和治疗结果.
- 拟议的优化支架几何结构为冠状动脉疾病治疗提供了潜在的改进.
- 增材制造可以制造复杂的,优化的支架设计,用于临床评估.
相关概念视频
Stress Concentrations
273
Stress concentration is when stress intensifies near discontinuities such as holes or abrupt cross-sectional changes in a structural member. This localized stress can often surpass the average stress within the member. The stress distribution in flat bars, either with a circular hole or varying widths connected by fillets, can be determined experimentally using a photoelastic method. The results are based on ratios of geometric parameters like the ratio of the hole's radius to the smaller...
273
Stresses under Combined Loadings
146
When analyzing a bent tube with a circular cross-section subjected to multiple forces, it is crucial to determine the stress distribution in order to maintain structural integrity under varied load conditions.
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...
146
Coronary Artery Disease V: Surgical Management
3
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
3
Unsymmetric Loading of Thin-Walled Members
101
Thin-walled members with non-symmetrical cross-sections are vital to engineering structures, offering material efficiency and structural integrity. However, unsymmetrical loading on these members leads to complex stress distributions, resulting in simultaneous bending and twisting can cause deformation or structural failure. The interaction between bending and twisting requires detailed analysis to ensure structural resilience.
The concept of the shear center is crucial in countering the...
The concept of the shear center is crucial in countering the...
101


