改变子宫内膜微生物群概况与重复植入失败的子宫内膜受体性差有关
Rongxue Zhang1, Miaomiao Wang1, Jixiang Zhong1
1Department of Reproductive Medicine, Huai'an Maternal and Child Health Care Center, Huai'an, Jiangsu, People's Republic of China.
American journal of reproductive immunology (New York, N.Y. : 1989)
|October 29, 2024
概括
无法解释的重复植入失败 (RIF) 与子宫内膜微生物群失生症和子宫内膜受体性降低有关. 改变的微生物组成,特别是较低的Lactobacillus和较高的Gardnerella/Acinetobacter,与受体能力受损相关,这表明RIF的因果作用.
科学领域:
- 生殖医学 生殖医学
- 微生物组研究 微生物组研究
- 妇科病理学 妇科病理学
背景情况:
- 无法解释的重复植入失败 (RIF) 在辅助生殖技术中构成了重大挑战.
- 在RIF中子宫内膜微生物组的作用仍然不完全理解.
研究的目的:
- 为了研究RIF的妇女的子宫内膜微生物群特征.
- 探索子宫内膜微生物群组成和子宫内膜受容性标记物之间的关系.
主要方法:
- 从RIF患者 (n=32) 和对照组 (n=18) 收集了阴道分泌物和子宫内膜活检样本.
- 使用16S rRNA测序和qPCR来分析微生物群组成.
- 评估子宫内膜受体性标志物,并与微生物群数据进行相关性分析.
主要成果:
- 与对照组相比,子宫内膜微生物群在RIF组中显示出更高的α多样性.
- RIF患者表现出乳酸菌减少和加德内雷拉和阿辛托巴克特丰富度增加.
- 在RIF组中观察到关键子宫内膜受容性标志物的表达较低,与微生物失衡相关.
结论:
- RIF与子宫内膜微生物群失生症和受损的子宫内膜受体性有关.
- 异常的子宫内膜微生物组合是导致无法解释的RIF的潜在因素.
- 准子宫内膜微生物群可能为RIF提供新的治疗策略.
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