与截肢后标准外周神经管理相比,有针对性的肌肉再生神经:系统性审查和元分析
Alexis J Zimbulis1, Vincent V G An2, Michael Symes2,3,4
1University of Notre Dame School of Medicine, Darlinghurst, New South Wales, Australia.
概括
与标准治疗相比,有针对性的肌肉再生 (TMR) 显著减少截肢后的幻肢疼痛 (PLP) 和残余肢痛 (RLP). TMR还改善了功能并减少了阿片类药物使用,主要的TMR显示出更好的结果.
科学领域:
- 再生医学是一种再生医学.
- 手术创新 在外科创新.
- 疼痛管理 疼痛管理
背景情况:
- 截肢通常会导致慢性疼痛,包括幻肢疼痛 (PLP) 和残余肢痛 (RLP).
- 向肌肉再生 (TMR) 是一种通过重定向残余神经来恢复运动功能的手术技术.
- 目前对截肢后疼痛的治疗方法存在重大挑战.
研究的目的:
- 系统地审查和比较TMR与截肢后标准神经治疗 (SNT) 的结果.
- 分析患者报告和功能结果.
- 检查初级和二级TMR之间的差异,以及并发症患者的结局.
主要方法:
- 对中央数据库进行了系统的文献搜索.
- 对从已识别的研究中提取的数据进行了元分析.
- 十一项研究符合审查的纳入标准.
主要成果:
- 与SNT相比,TMR显著降低了PLP和RLP,基于多个疼痛评估得分.
- 接受TMR治疗的患者经历了功能改善和减少阿片类药物消费.
- 主要TMR (截肢时) 的疼痛分数比次要TMR更好.
结论:
- TMR是一种有益的外科辅助剂,用于控制截肢患者的疼痛和改善功能.
- 需要进行进一步的研究,特别是关于伴随疾病患者的TMR结果.
- TMR代表了截肢后护理的一个有前途的进步.
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