相关实验视频
Updated: Jun 9, 2025

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
与代谢功能障碍相关的脂肪性肝病的药物治疗:进展和方向
Da Zhou1,2, Jiangao Fan3,4
1Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球数百万人. 包括已批准的resmetirom在内的新药疗法在治疗代谢功能障碍相关的脂肪肝炎 (MASH) 和相关纤维化方面表现有前途.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个全球性流行病,而代谢功能障碍相关的脂肪性肝炎 (MASH) 代表了其关键的,渐进的阶段.
- 早期诊断和MASH的干预对于预防严重的肝内外并发症至关重要.
- 目前对MASH的药物治疗选择仍然有限,原因是复杂的病原和疾病异质性.
研究的目的:
- 审查目前MASH药物治疗的现状.
- 总结最近对新型MASH药物的临床试验结果.
- 概述MASH药物开发的未来研究方向和挑战.
主要方法:
- 对MASH疗法的当前文献和最近的2/3期临床试验数据的综述.
- 专注于向肝炎和纤维化所涉及的关键途径的药物.
- 分析已批准的药物和即将获得监管批准的药物.
主要成果:
- 甲状腺激素受体-β激动剂Resmetirom是治疗纤维化MASH的第一个经批准的药物.
- 其他几种药物类别,包括PPAR激动剂,GLP-1类似物和FGF21类似物,都处于后期临床开发阶段,有前景的结果.
- 试验性药物通过向不同的致病途径来证明有效性,包括脂肪肝炎和纤维化.
结论:
- 在MASH药物治疗方面正在取得重大进展,最近批准resmetirom标志着一个里程碑.
- 多种新型药物正在进行临床试验,为改善MASH管理提供了希望.
- 为了解决MASH的复杂性和异质性,持续的研究对于有效的治疗策略至关重要.
更多相关视频
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
04:14Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
Published on: April 16, 2019
相关概念视频
Chronic Pancreatitis II: Collaborative Care
Assessment:
Liver Physiology
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...