在患有非阻塞性冠状动脉的胸痛患者中,运动训练的影响:系统性审查和元分析
Yuan Wu1, Haixiang Zhu1, Qijin Xu1
1Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine.
Coronary artery disease
|October 29, 2024
概括
运动训练 (ET) 在患有非阻塞性冠状动脉 (ANOCA) 的胸痛患者中显著改善心肺功能,运动能力和内皮功能. 这一元分析表明,ET是ANOCA的推治疗方法.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 内部医学 内部医学
背景情况:
- 非阻塞性冠状动脉 (ANOCA) 的胸痛是一种常见的心血管疾病.
- 目前支持运动训练 (ET) 作为ANOCA治疗的证据有限.
- 需要对ET在ANOCA患者的疗效进行全面评估.
研究的目的:
- 系统地评估运动训练 (ET) 对被诊断为患有非阻塞性冠状动脉 (ANOCA) 的胸痛的患者的影响.
- 为ANOCA提供现有ET研究的综合元分析.
- 评估心肺功能,运动能力和内皮功能的改善.
主要方法:
- 在多个数据库 (PubMed,Embase,Cochrane Library,Web of Science,CNKI,VIP,WanFang) 进行了系统的文献搜索,截至2024年1月15日.
- 在分析中包括了12项研究.
- 使用Cochrane偏差风险工具评估研究质量,使用Cochran的Q测试和I2统计数据评估异质性. 根据性别进行了子组分析.
主要成果:
- 运动训练 (ET) 显著改善了氧气吸收峰值 (VO2峰值),左心室喷射率和6分钟步行测试.
- 内皮功能的关键标志物,包括氧化和外周动脉度测量,在ET组显著更高.
- 在ET之后,矩阵金属蛋白酶-9水平显著降低.
结论:
- 运动训练 (ET) 对患有非阻塞性冠状动脉 (ANOCA) 的心痛患者显示出显著的益处.
- ET改善心肺功能,增强运动能力,并促进ANOCA患者更好的内皮功能.
- 这些发现支持推ET作为ANOCA的治疗干预.
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