装有凯托可纳的可3D打印的酸盐-酸盐水凝表现出抗菌活性
Manoela Almeida Martins Mace1,2,3, Camila Leites Reginatto3,4, Victória Rapack Jacinto Silva5,6
1Programa de Pós-Graduação Em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Biopolymers
|October 29, 2024
概括
研究人员开发了一种可3D打印的水凝,用于治疗真菌性皮肤感染. 这种可生物降解的材料有效地提供了可纳,对Cryptococcus neoformans表现出强大的抗真菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 菌类学 菌类学是指菌类学.
- 药物输送系统 药物输送系统
背景情况:
- 菌感染,特别是由Cryptococcus neoformans引起的皮肤菌,具有有限的治疗选择和高的复发率.
- 目前针对加密球菌病的治疗方法往往是系统性的,昂贵的,缺乏针对皮肤表现的局部方法,每年影响18万人的生命.
- 正在探索自然聚合物在医疗保健领域的先进应用,包括感染治疗.
研究的目的:
- 开发一种可3D打印,可生物降解的聚合物水凝,用于局部输送可纳.
- 评估含有基托可纳的水凝对Cryptococcus neoformans的可打印性,风湿性质和抗真菌功效.
- 评估开发的水凝的稳定性和初步细胞毒性,以潜在的体内应用.
主要方法:
- 制造一个可3D打印的生物可降解的聚合物水凝,装载着基托可纳.
- 描述水凝特性,包括3D打印能力,质学 (伪塑性行为) 和FTIR光谱,以确认酸盐-Ca+2相互作用 (蛋箱模型).
- 通过抑制区对C. neoformans菌株的抗真菌活性评估,并通过使用V79细胞进行胀研究和初步细胞毒性测试来评估物质稳定性.
主要成果:
- 开发的水凝显示出出色的3D打印能力和理想的伪塑性质的质性质.
- 通过FTIR分析证实了通过酸盐-Ca+2卵箱模型进行交叉链接.
- 含有可纳的水凝对C. neoformans表现出显著的抗真菌活性,稳定性高达12天,有前性的初步细胞毒性结果.
结论:
- 一种可3D打印的,生物降解的凝,装有可纳,已经成功开发出来.
- 水凝配方显示强大的抗真菌活性对Cryptococcus neoformans,适合局部应用.
- 该材料的稳定性和初步安全性概况表明它有可能用于进一步的体内研究和皮肤真菌感染的临床转化.
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