在多发性肌痛风湿症和巨细胞动脉炎中使用巴里西替尼:报告了6例病例
Dario Camellino1, Christian Dejaco2, Franco Martini3
1Division of Rheumatology, "La Colletta" Hospital, Azienda Sociosanitaria Ligure 3, Arenzano.
Reumatismo
|October 29, 2024
概括
巴里西替尼 (BARI) 在治疗多发性肌痛性风湿症 (PMR) 和巨细胞动脉炎 (GCA) 中表现有前途,减少疾病活性,并允许减少葡萄糖皮质激素 (GC) 的使用. 这个案例系列突出显示了BARI BARI.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多发性肌痛风湿症 (PMR) 和巨细胞动脉炎 (GCA) 是一种炎症性疾病,通常需要长期使用葡萄糖皮质类药物 (GC) 治疗.
- 耐药性疾病过程或药物不可用 (例如,大流行期间的托西利祖马布) 需要替代治疗策略.
- 简氏激酶 (JAK) 抑制剂代表了管理这些自身免疫性疾病的潜在途径.
研究的目的:
- 评估巴里西提尼布 (BARI) 在PMR和/或GCA.患者的疗效和安全性.
- 评估BARI作为该患者队列中的葡萄糖皮质类药物节约剂的潜力.
- 描述耐药性疾病或对其他治疗方法的限制患者的治疗结果.
主要方法:
- 采用了病例系列设计,涉及六名被诊断为PMR和/或GCA的患者.
- 由于耐火性疾病或托西利祖马布不可用,患者接受了巴里丁 (BARI) 治疗.
- 在BARI治疗之前和之后,疾病活性评分 (PMR活性评分) 和普雷尼松剂量都被监测.
主要成果:
- 所有六名患者都报告说,巴里西提尼布 (BARI) 治疗的临床改善.
- 在BARI治疗6个月后,中位数PMR活性得分从23.3显著下降到1.58.
- 两名患者成功地停止了葡萄糖皮质类药物 (GC) 治疗,并继续接受BARI单一治疗. 一名患者出现了肺炎,导致BARI停止治疗.
结论:
- 巴里西丁尼 (BARI) 在治疗多肌痛性风湿性 (PMR) 和巨细胞动脉炎 (GCA) 中表现出有效性.
- 巴里显示出作为一种糖皮质激素节约策略的潜力,使PMR和GCA患者的GC依赖性降低.
- 考虑到安全性和疗效,对PMR和GCA的JAK抑制剂进行进一步的研究是有必要的.
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