微针作为一种新兴的通过皮肤传递植物化学品的平台
B H Jaswanth Gowda1,2, Mohammed Gulzar Ahmed2, Raghu Raj Singh Thakur1
1School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast BT9 7BL, United Kingdom.
Molecular pharmaceutics
|October 29, 2024
概括
微针 (MNs) 与口服或传统的皮肤输送相比,提供一种优越的方法来输送植物衍生药物化合物 (植物化学物质). 这种先进的方法克服了生物可用性问题,提高了治疗疗效.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 植物医学研究 植物医学研究
- 生物材料和纳米技术
背景情况:
- 植物化学物质具有显著的治疗潜力,但面临着诸如口服生物可用性差和胃肠道不稳定性等局限性.
- 传统的内/透皮输送方法表现有希望,但由于皮肤透性差,释放缓慢和吸收不一致而受到阻碍.
- 微针 (MNs) 成为一种新的解决方案,以克服这些植物化学品的交付挑战.
研究的目的:
- 审查当前植物化学物质输送系统的局限性.
- 突出内/透皮输送的优点,特别是使用微针 (MN).
- 探索基于MN的植物化学物质的设计,应用和未来前景.
主要方法:
- 关于植物化学物质输送路径的综合文献综述.
- 分析微针技术用于内/透皮药物输送.
- 检查MN设计原则,以实现最佳的植物化学载荷和释放.
- 审查在特定疗法中的MN应用,如光动力学疗法.
主要成果:
- 微针显著提高了通过皮肤屏障的植物化学透.
- MNs提供精确控制药物释放动力学,提高吸收效率.
- 这项技术绕过了与植物化学物质相关的口服生物可用性和胃肠道稳定性问题.
结论:
- 微针技术代表了内/透皮植物化学物质输送的变革性进步.
- 优化MN设计对于植物衍生疗法的有效和有针对性的交付至关重要.
- MN介导的交付对包括光动力学疗法在内的各种应用具有前景,目前正在进行专利活动,并有未来的潜力.
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