脑下核神经元在语音过程中编码音节序列和语音特征.
W J Lipski1,2, A Bush3,4, A Chrabaszcz5
1Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Journal of neurophysiology
|October 29, 2024
概括
基底的亚体核 (STN) 中的神经元编码语音的序列和语音内容. 这一发现揭示了大脑如何控制复杂的发声和运动序列.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 语音制作 语音制作
背景情况:
- 基底腺节在运动控制中起着至关重要的作用,但它们对语音产生的具体贡献仍在争论中.
- 计算模型提出基底可能编码语音内容或语音元素序列.
研究的目的:
- 调查语音和语音序列特征与下丘脑核 (STN) 神经元发射率之间的关系.
- 为了确定STN神经元是否编码语音内容,语音序列或两者.
主要方法:
- 在帕金森病患者的深度大脑刺激 (DBS) 电极植入过程中,从传感运动STN记录了单个单元的细胞外潜力.
- 患者在响应音频提示时重复了三个辅音母音 (CV) 音节的随机序列.
- 使用线性回归分析了神经元发射速率与语音标识和音节序列的关系.
主要成果:
- 在记录的STN神经元中,超过一半 (50%) 的STN神经元显示了与任务相关的显著火速增加,而23%的STN神经元显示了火速下降.
- 增加和减少STN神经元的发射人群编码了产生的语音的语音和序列特征.
- 最大音符编码发生在音符生产的时间左右,这表明是感官处理而不是运动计划.
结论:
- 基底质中的亚thalamic核 (STN) 包含单个神经元,它们分别代表语音序列和语音选择.
- 这些发现促进了对人类语音产生的神经基础的理解,以及复杂行为中的基底腺功能.
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