在成功重新道化后,功能独立延迟失败的炎症指数
Mengke Zhang1, Wenbo Zhao1, Chuanjie Wu1
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
The International journal of neuroscience
|October 29, 2024
概括
系统性炎症的标志物,包括中性粒细胞与淋巴细胞的比率 (NLR) 和系统性免疫炎症指数 (SII),与急性缺血性中风 (AIS) 转流后神经系统改善的延迟 (fDNI) 的失败有关. 这些发现可能有助于预测中风治疗后患者的结果.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 经过急性缺血性中风 (AIS) 成功重新道化后,延迟神经改善 (fDNI) 的失败很常见.
- 系统性炎症标志物,如中性粒细胞与淋巴细胞比率 (NLR) 和系统性免疫炎症指数 (SII),正在研究它们在fDNI中的作用.
研究的目的:
- 为了研究系统性炎症标志物和fDNI之间的关联,在成功实现再输血的AIS患者中.
- 在这个患者队列中确定fDNI的预测因子.
主要方法:
- 对从2017年1月到2020年4月接受血栓切除术的AIS患者进行前性研究.
- 用多变量后勤回归和ROC曲线分析来确定fDNI预测因素.
主要成果:
- 在对混因素进行调整后,NLR和SII显示了与fDNI的独立关联.
- 对于NLR和SII的多变量模型,AUC分别为0.862和0.861.
- 84名患者 (23.86%) 经历了fDNI,而268名 (76.14%) 没有.
结论:
- 免疫炎症生物标志物NLR和SII与AIS患者的fDNI有关,而没有早期的神经改善.
- 需要进一步的研究来了解这些关联背后的机制.
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