Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

PulseGAN: Learning to Generate Realistic Pulse Waveforms in Remote Photoplethysmography.

IEEE journal of biomedical and health informatics·2021
Same author

Dexmedetomidine post-conditioning ameliorates long-term neurological outcomes after neonatal hypoxic ischemia: The role of autophagy.

Life sciences·2021
Same author

[Corrigendum] Ski prevents TGF‑β‑induced EMT and cell invasion by repressing SMAD‑dependent signaling in non‑small cell lung cancer.

Oncology reports·2021
Same author

Synergistic Effects of Alpha Olefin Sulfonate and Sodium Alginate on Inkjet Printing of Cotton/Polyamide Fabrics.

Langmuir : the ACS journal of surfaces and colloids·2021
Same author

Diagnostic value of microRNA-25 in patients with non-small cell lung cancer in Chinese population: A systematic review and meta-analysis.

Medicine·2020
Same author

Development and external validation of a COVID-19 mortality risk prediction algorithm: a multicentre retrospective cohort study.

BMJ open·2020

相关实验视频

Updated: Jun 9, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K

免疫细胞和多聚肌炎之间的因果关系:孟德尔的随机化分析.

Ni Yang1, Chang Li2, Ruhui Liu2

  • 1Department of First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.

Medicine
|October 29, 2024
PubMed
概括

这项研究揭示了特定免疫细胞和多质神炎之间的显著因果关系,确定了潜在的生物标志物和治疗点. 研究结果表明,多聚肌炎和皮肤肌炎之间存在共享的免疫调节机制.

更多相关视频

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.6K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K

相关实验视频

Last Updated: Jun 9, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.6K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K

科学领域:

  • 免疫学 免疫学 免疫学
  • 遗传学 遗传学 是一个
  • 自免疫性疾病 自免疫性疾病

背景情况:

  • 聚髓炎是一种异常性炎症性肌肉病变,被认为是自身免疫源.
  • 关于免疫细胞和多质神经炎之间的特定相互作用的研究有限.
  • 需要进一步的研究来理解这些复杂的关联.

研究的目的:

  • 通过双向门德尔随机化 (MR) 分析,研究731种免疫细胞类型和多聚肌炎之间的因果关系.
  • 为了比较免疫细胞协会在多质神炎与那些在皮肤神炎.
  • 为了识别潜在的免疫细胞生物标志物,用于polymyositis.

主要方法:

  • 双向门德尔随机化 (MR) 分析,涉及731个免疫细胞和多质神炎.
  • 使用逆方差加权 (IVW) 方法进行初级分析,并得到四种额外的MR技术的支持.
  • 评估异质性 (科克兰Q测试),型 (MR-Egger) 和异常值的识别 (MR-PRESSO).
  • 抛出一个的分析,以评估仪表变量的稳定性.

主要成果:

  • 前进MR发现了10个具有保护作用的免疫细胞和16个具有高发多菌炎风险的免疫细胞.
  • 反向MR指示的多聚菌炎影响2个免疫细胞的水平和5个免疫细胞表现型的表达.
  • 观察到多聚炎和特定免疫细胞表型之间存在复杂的相关性:CD8,CD33dim,HLA-DR,CD11b和CD45.
  • 十五种免疫细胞类型显示了多聚肌炎和皮肤肌炎之间的共同因果关系.
  • 在各个分析中没有检测到显著的异质性或水平变性.

结论:

  • 这项研究提供了强有力的证据,证明了各种免疫细胞和多质神炎之间的因果关系.
  • 聚髓炎和皮肤肌肉炎具有共同的调节机制,涉及特定的免疫细胞.
  • CD8,CD33dim,HLA-DR,CD11b和CD45被确定为多质神炎的潜在免疫细胞生物标志物.
  • 这些发现为开发多菌炎的预后和治疗策略提供了新的见解.