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Updated: Jun 9, 2025

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来自IMPA1的伊诺西托尔通过IMPDH2激活来维持割抵抗性前列腺癌的干性

Che-Chia Hsu1,2, Guihua Wang2, Chien-Feng Li3

  • 1Department of Pathology, Duke University Medical Center, Duke University School of Medicine, Durham, NC, USA.

The Journal of experimental medicine
|October 29, 2024
PubMed
概括

由IMPA1产生的内醇为前列腺癌干细胞 (PCSCs) 提供燃料,并驱动对雄激素切除疗法 (ABT) 的耐药性. 向IMPA1/inositol/IMPDH2通路可以阻止割抵抗性前列腺癌 (CRPC) 的进展.

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