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Updated: Jun 9, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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2025年的MOBIDB:整合固有无序蛋白质的集合性质和功能注释

Damiano Piovesan1, Alessio Del Conte1, Mahta Mehdiabadi1

  • 1Department of Biomedical Sciences, University of Padova, Padua 35131, Italy.

Nucleic acids research
|October 29, 2024
PubMed
概括

现在,MobiDB提供了增强的蛋白质疾病信息,以更快的预测和改进的数据访问. 这一更新为研究人员提供了对内在疾病功能和结构细节的更深入的见解.

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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