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Updated: Jun 9, 2025

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
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人类羊上皮干细胞通过调节巨细胞的极化,促进大鼠脊髓损伤后的功能恢复.

Hongyan Zhang1, Jingjing Liu1, Beike Chen1

  • 1Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Molecular neurobiology
|October 29, 2024
PubMed
概括

在大鼠中,人类羊上皮干细胞 (hAESCs) 在脊髓损伤 (SCI) 后显著改善运动功能的恢复. 较高剂量通过减少炎症和促进神经修复,显示出更好的结果.

关键词:
人类羊膜上皮干细胞人类羊膜上皮干细胞.运动器功能 运动器功能神经炎症是一种神经炎症.神经保护是一种神经保护.脊髓损伤导致的脊髓损伤

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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