相关实验视频
Updated: Jun 9, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
在意大利东北部的一项基于人口的大型研究中,自身免疫性甲状腺炎的发生率
Simona Censi1,2, Laura Salmaso3, Filippo Ceccato1,2
1Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Endocrine
|October 29, 2024
概括
自免疫性甲状腺炎 (AT) 发病率在意大利威尼托地区在2013-2022年期间下降,特别是在女性中,与改善的状况相关. 由于SARS-CoV-2大流行,AT率暂时下降.
科学领域:
- 内分泌学 在内分泌学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 意大利威尼托地区的状况在过去十年中有所改善.
- 了解自身免疫性甲状腺炎 (AT) 的发病率趋势对于公共卫生规划至关重要.
研究的目的:
- 估计自免疫甲状腺炎 (AT) 在威尼托地区在2012年至2022年间的发病率.
- 调查改善的状态和AT发病率趋势之间的关联.
主要方法:
- 一项回顾性,基于人口的研究,利用威尼托的人口登记册和行政卫生数据库.
- 从2013年到2022年确定了突发性甲状腺功能障碍病例,以排除流行病例.
- 标准化发病率 (IR) 每1万人/年按年龄和性别计算.
主要成果:
- 总共有65,379个事件AT病例被确定 (IR:13.38),女性的发病率比男性高5.44倍.
- 总体IR从2013年的15.86下降到2022年的12.35,这一下降主要观察到的是女性,尤其是15-54岁的女性.
- 2020年发生了AT发病率显著下降的趋势,与SARS-CoV-2流行病相吻合.
结论:
- 在过去的十年中,威尼托地区自身免疫性甲状腺炎的发病率有所下降,与状况的改善并行.
- 只有在女性中,特别是生育年龄的女性中,AT发病率的减少在统计学上是显著的.
- SARS-CoV-2 流行病暂时影响了AT发病率趋势,随后的发病率重新调整.
相关概念视频
Autoimmune Disorders
390
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
390
Non-LTR Retrotransposons
11.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.4K
Gastritis-II: Pathophysiology
262
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
262

