与代谢综合征相关的帕金森病患者的痴呆风险增加
Esma Kobak Tur1, Helin Berfin Kutlu2, Nisa Sever2
1Department of Neurology, University of Health Sciences, Fatih Sultan Mehmet Research and Training Hospital, Hastane Sok. No: 1/8 Içerenköy - Ataşehir, Istanbul, 34752, Turkey. esmakbk@hotmail.com.
概括
代谢综合征显著影响帕金森病患者的认知能力,增加痴呆的风险. 早期发现和管理代谢综合征可能有助于减缓帕金森病的认知衰退.
科学领域:
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
- 认知科学 认知科学
背景情况:
- 代谢综合征 (MetS) 与帕金森病 (PD) 有着共同的病理生理联系.
- 在一般人群中,MetS是认知障碍的确立危险因素.
- 在PD患者中,MetS与认知之间的关系需要进一步研究.
研究的目的:
- 为了研究代谢综合征对早期帕金森病患者认知功能的影响.
- 为了确定这个患者队列中MetS的流行率.
- 评估MetS与不同程度的认知障碍之间的关联,包括帕金森病痴呆症 (PDD).
主要方法:
- 招募了早期帕金森病患者.
- 代谢综合征的诊断遵循了国家胆固醇教育计划成人治疗小组III标准.
- 用蒙特利尔认知评估尺度 (MoCA-TR) 的土耳其版本评估认知功能,将参与者分为正常认知,轻度认知障碍PD-MCI和PDD.
主要成果:
- 代谢综合征在39.6%的参与者中被发现.
- 与没有mets的患者相比,mets患者的认知分数明显较低.
- 较高的禁食血糖水平与视觉空间,执行,命名,语言和定向得分相反相关.
- MetS与发展PDD的风险增加了11.3倍 (OR:11.3,95% CI:1.61-79.2).
结论:
- 帕金森病患者中代谢综合征的存在与痴呆症进展的可能性增加有关.
- 将代谢综合征评估纳入帕金森病患者的管理可能有助于有效控制认知衰退和痴呆.
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