马方综合征与妇科疾病和孕产妇并发症风险增加有关
Marisa R Imbroane1, Cydni Akesson2, Hanna Kim3
1School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Journal of assisted reproduction and genetics
|October 29, 2024
概括
患有马方综合征的女性面临更高的生殖问题风险,包括疼痛,异常出血和子宫内膜异位症. 他们也增加了产科并发症,如妊娠高血压和子宫前.
科学领域:
- 生殖医学是一种生殖医学.
- 遗传学 是一个遗传学.
- 产科和妇科 产科和妇科
背景情况:
- 马方综合征是一种遗传连接组织疾病,影响多个器官系统.
- 患有马方综合征的妇女的生殖健康需要进一步调查.
研究的目的:
- 评估被诊断为马凡综合征的女性患者生殖系统疾病的风险.
- 为了确定与马凡综合征相关的特定的妇科,生育和产科结果.
主要方法:
- 使用TriNetX研究网络进行的回顾性队列研究.
- 包括4347名年龄在18-44岁之间的患有马尔方综合征 (ICD-10 Q87.4) 的女性患者.
- 结果与16,424,990名没有Marfan或Ehlers-Danlos综合征的患者的对照组进行了比较,通过ICD-10代码分析了妇科,泌尿外科,生育和产科诊断.
主要成果:
- 马凡综合征患者的骨盆疼痛,经期障碍,异常子宫出血和子宫内膜异位症的风险显著增加 (p <0.0001).
- 观察到失足症,乳腺瘤,生殖器落和尿失禁的风险增加.
- 与对照人群相比,生育测试,剖腹产,妊娠高血压和子宫前的发生率增加.
结论:
- 患有马方综合征的患者患有各种生殖系统疾病的患病率更高.
- 马方综合征与产科并发症的增加有关,因此在怀孕期间需要谨慎管理.
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