大型组织相容性复杂多态与肉急性阶段反应的关联
Afra Vatankhah1, Gholamreza Nikbakht Brujeni1, Atefeh Esmailnejad2
1Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Veterinary medicine and science
|October 29, 2024
概括
主体组织相容性复合体 (MHC) 基因多态性影响肉的急性阶段反应 (APR). 特定的MHC等位基因与免疫标记物相关,有助于对疾病耐药性的遗传选择.
科学领域:
- 动物遗传学动物遗传学
- 免疫学 免疫学 免疫学
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 主体免疫受环境,内源性或传染性因素的压力影响.
- 的遗传多样性对于免疫挑战的抗性和易感性变化至关重要.
研究的目的:
- 为了研究主要基因相容性复合体 (MHC) 多态性和急性阶段反应 (APR) 在罗斯308肉之间的关联.
- 在压力条件下识别与免疫反应标志物相关的特定MHC等位基因.
主要方法:
- 在120只罗斯肉中确定LEI0258微卫星标记物的等位体多样性.
- 分析了急性阶段蛋白 (APP),如血清粉样蛋白A (SAA) 和α-1-酸糖蛋白 (AGP),作为APR标记物.
- 检查的白细胞数量,异质细胞/淋巴细胞 (H/L) 比率,以及对纽卡斯尔病疫苗 (NDV) 的抗体反应.
主要成果:
- 鉴定了六个MHC等位基因 (195448 bp).
- 在罗斯群体中,MHC等位基因显著影响了Ross群体中的APP (p < 0.05).
- 基因组448与SAA和H/L比率相关;基因组207与AGP相关;基因组195与AGP,基底和单细胞化有负相关.
结论:
- 在肉中,MHC作为免疫反应的显著候选基因标记物.
- 在MHC等位基因分析中,可以支持疫苗设计和对疾病耐药性的基因改进.
- 了解MHC多态性有助于商业肉生产的资源保护.
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