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Updated: Jun 9, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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长时间暴露于胰岛素可能会导致表观遗传改变,导致胰岛素耐药性

Shehnaz Bano1,2, Shyam More1,2, Dattatray S Mongad1

  • 1National Centre for Cell Science, Pune, India.

FEBS open bio
|October 29, 2024
PubMed
概括

在没有高葡萄糖的情况下,长时间暴露于胰岛素会通过损害PI3K/AKT信号来引起胰岛素抵抗. 这种胰岛素抵抗与表观遗传变化有关,可以通过表观遗传修饰剂逆转.

关键词:
通过RNA测序进行RNA测序.表观遗传修饰剂 表观遗传修饰剂基因组胺甲基化 基因组胺甲基化胰岛素耐药性是一种胰岛素耐药性.鼠标模型 鼠标模型鼠标模型

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