结合放射和美国评估来解读SSc患者手中的关节参与
Marine Tas1, Romain Lecigne1, Nicolas Belhomme2,3
1Department of Radiology, CHU Rennes, Univ Rennes, Rennes, France.
Rheumatology (Oxford, England)
|October 29, 2024
概括
骨质植物症显著导致硬化皮肤病 (SSc) 患者的关节问题. 即使排除了混因素,超过10%的SSc患者表现出活跃的突炎,这表明特定的SSc相关的关节参与.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 硬化症 (SSc) 是一种结缔组织疾病,其特征是纤维化,血管异常和免疫系统失调.
- 突和紧突参与是SSc中公认的表现,但它们的特定病因和促成因素需要进一步阐明.
- 了解这些因素对于准确诊断和管理SSc相关的肌肉骨并发症至关重要.
研究的目的:
- 调查SSc患者的突和紧突干扰的原因和促成因素.
- 描述SSc患者的临床和成像表型,这些患者具有突和紧突特征.
- 确定SSc.中活跃突炎和紧突炎的患病率和相关性.
主要方法:
- 一组171名SSc手部表现的患者接受了标准X射线和手部超声波 (美国).
- 检查了X射线的骨解脱,化,微晶,退行性变化和骨质植物病.
- 美国被一个盲目评估者用来评估活跃或纤维性突炎和紧突炎的存在.
主要成果:
- 多变量分析确定CRP>10 mg/l,US上的纤维性紧缩性炎,抗RNA聚合酶III抗体和X射线上的多骨生与活跃的炎/紧缩性炎相关.
- 在排除了类风湿性关节炎和多骨生病后,12.7%的SSc患者仍然在美国表现出活跃的突炎/紧炎.
- 在这个选定的群体中,硬质皮质性危机和US上的纤维性综合炎与活跃的综合炎/综合炎显著相关.
结论:
- 根据现实世界的数据,骨质植物病被证实是SSc患者联合参与的重要贡献者.
- 在排除混因子后,持续发现活跃的突炎/紧突炎 (>10%),这表明有明显的SSc相关的突和/或紧突过程.
- 这些发现强调了像超声波这样的成像方法在评估SSc相关的肌肉骨表现方面的重要性.
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