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Updated: Jun 9, 2025

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
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Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide

Published on: May 12, 2023

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一个分层的肝脏新生脂质生成基质供应网络,利用pyruvate,乙酸和酸盐

Adam J Rauckhorst1, Ryan D Sheldon2, Daniel J Pape2

  • 1Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Fraternal Order of Eagles Diabetes Research Center (FOEDRC), University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; FOEDRC Metabolomics Core Research Facility, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.

Cell metabolism
|October 29, 2024
PubMed
概括

研究人员确定了控制肝脏脂肪产生的关键途径,这对于理解和治疗代谢疾病至关重要. 这项研究揭示了 mitochondrial pyruvate 载体 (MPC) 和 ATP - 酸酶 (ACLY) 是如何在肝脏 de novo 脂质生成 (DNL) 中发挥核心作用.

关键词:
一个 AACS 的 AACS.艾克利·阿克利 (aclyly) 是一个在ACSS2中使用ACSS2.在ATP-酸盐溶解酶中.公民 公民 公民德语:DNL 德语:DNL 德语:DNL 德语:DNL在MPC中,MPC是MPC.乙酸乙-CoA合成酶的使用乙烯基-CoA合成酶2的使用在新的脂质生成中.肝脏 肝脏 肝脏 肝脏 肝脏 肝脏代谢生物组的代谢生物组线粒体酸盐载体是线粒体的酸盐载体.线粒体中的pyruvate载体稳定同位素的标记物是稳定的.

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