通过微针进行喷射注射,用于大量的皮下输送
James William McKeage1, Andrew Zheng Hao Tan1, Andrew James Taberner2
1Auckland Bioengineering Institute, the University of Auckland, Auckland, New Zealand.
International journal of pharmaceutics
|October 29, 2024
概括
这项研究引入了基于微针的喷射注射,用于大量的皮下药物输送,使目前设备的容量几乎翻了一番. 这一创新增强了患者自给药的选择,以获得更大的药物量.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 微针技术 微针技术
背景情况:
- 皮下 (SC) 药物输送提供了与自给药一样的优势,但仅限于约2.25毫升.
- 对于超过SC限量的体积,需要静脉注射 (IV),增加成本和复杂性.
研究的目的:
- 开发和评估一种新型的多喷射微针系统,用于大量的SC药物输送.
- 为了克服当前SC注射方法的体积限制.
主要方法:
- 开发了一种新的多喷气原型,使用缩短的30G针 (曝光长度约1毫米).
- 测量了喷气体的特性 (速度,形状,体积).
- 使用ex vivo猪组织来测试高达3.9毫升的注射量.
主要成果:
- 通过使用微针喷射注射,在0.3秒内成功输送 (>95%) 3.9毫升.
- 喷射速度低于70米/秒,导致3.9毫升体积的不完全输送.
- 与无针注射相比,微针辅助分娩在大量情况下显示出更一致的结果.
结论:
- 通过微针进行多喷射注射有效地使大量的SC药物输送成为可能,几乎使当前的自动注射器容量翻了一番.
- 这项技术有望将患者的自我管理扩展到更广泛的治疗应用.
- 优化的喷气速度对于使用这种微针系统完成大批量交付至关重要.
相关概念视频
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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
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The IV route is often...
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Transdermal patches transport drugs through the...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...


