在婴儿和儿童模型中,Albuterol压力计量剂量吸入器的传递效率通过小尺寸喉膜口罩气道
Ariel Berlinski1, Jessica Fonzie2, L Denise Willis2
1Dr Berlinski is affiliated with Department of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, Arkansas; Pediatric Aerosol Research Laboratory, Arkansas Children's Research Institute, Little Rock, Arkansas; and Respiratory Care Services, Arkansas Children's Hospital, Little Rock, Arkansas.
Respiratory care
|October 29, 2024
概括
使用一个门保持室 (VHC) 与一个计量剂量吸入器 (MDI) albuterol在呼气过程中和一个小喉膜呼吸道 (LMA) 提高药物输送效率在儿科患者. 一个适配器装置被证明是低效的,导致呼吸回路中药物沉积很大.
科学领域:
- 麻醉学 麻醉学
- 儿科重症监护 儿科重症监护
- 呼吸系统医学 呼吸系统医学
背景情况:
- 在使用喉膜口罩呼吸道 (LMAs) 的儿科患者内科手术期间的支气管,通常使用来自压力计量剂量吸入器 (pMDI) 的阿尔布特罗尔来管理.
- 通过LMA优化阿尔布特罗尔的输送对于在儿科麻醉中有效管理支气管来说至关重要.
研究的目的:
- 在儿科机械通风模型中,在各种实验条件下,通过LMA评估pMDI阿尔布特罗尔输送的效率.
- 为了比较不同的设备,启动时间,潮体积,启动模式和LMA大小,以优化气溶药物输送.
主要方法:
- 使用放置在LMA和试验肺之间的过器来评估阿尔布特罗尔的输送效率,测量药物沉积在电路 (肘部) 和LMA中.
- 调查的关键变量包括设备类型 (式支室[VHC]与适配器),启动时间 (吸入与过期),潮体积 (50毫升与100毫升),启动模式 (单个与多个) 和LMA大小 (1, 1.5, 2).
- 使用多重回归分析来确定每个因素对药物递送效率和电路/LMA沉积的贡献.
主要成果:
- 与适配器 (0%) 相比,VHC (6.3%) 的药物递送效率显著更高.
- 使用VHC (2.9%) 的电路沉积比使用适配器 (25.8%) 低得多.
- 设备类型,呼气期间的启动时间和较小的LMA大小是影响输送效率的重要因素.
结论:
- 使用VHC,在呼气时激活pMDI,使用较小的LMA大小可以提高阿尔布特罗尔的输送效率.
- 适配器是通过LMAs传递pMDI阿尔布醇的无效装置,导致呼吸回路内大量药物沉积.
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