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Updated: Jun 9, 2025

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data
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De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

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工程作物性能与上游开放的阅读框架

Rui Mou1, Ruixia Niu1, Ruoying Yang1

  • 1State Key Laboratory of Hybrid Rice, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei 430072, China.

Trends in plant science
|October 29, 2024
PubMed
概括

转化控制通过调节基因表达来优化作物产量. 上游开放阅读框架 (uORF) 是关键的RNA调控元素 (RRE),通过精确的基因表达调制来提高农业生产力.

关键词:
基因编辑 基因编辑基因工程是基因工程,是基因工程.合成生物学 合成生物学转基因是指转基因的人类.翻译控制的翻译控制上游开放的阅读框架.

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Leaky Scanning02:28

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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