在慢性脏疾病中,尿中的肌氨酸分泌与骨矿物密度之间的关联:KNOW-CKD研究的结果
Sang-Eun Kim1, Sung Hoon Jung2, Jihyun Yang3
1Department of Hospital Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-Ro, Jongno-Gu, Seoul, 03181, Republic of Korea.
Journal of nephrology
|October 30, 2024
概括
低肌肉质量,以24小时尿中低肌素表示,与韩国慢性病 (CKD) 患者的骨矿物质密度较低有关. 这表明肌肉质量是CKD骨质疏松症的独立风险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 骨的新陈代谢 骨的新陈代谢
- 临床营养学 临床营养学
背景情况:
- 瘦体质与健康个体的骨矿物质密度有关.
- 慢性病 (CKD) 患者的肌肉质量和骨矿物质密度之间的关系尚不清楚.
- 这项研究调查了韩国CKD患者的肌肉质量和骨矿物质密度.
研究的目的:
- 评估韩国CKD患者的肌肉质量,以24小时尿液肌素 (UCr) 估计,与骨矿物质密度 (BMD) 之间的关系.
- 为了确定低肌肉质量是否与该人群的低BMD有关.
- 在透析前的CKD患者中识别骨质疏松症的潜在风险因素.
主要方法:
- 一项对1872名韩国CKD患者的横截面研究,来自KNOW-CKD队列.
- 肌肉质量估计使用24小时尿液肌素 (UCr) 水平.
- 用双能X射线吸收计测量腰椎,全部和股骨部的骨矿物质密度.
主要成果:
- 根据24小时UCr三位数 (T1-T3) 将患者分为三组.
- 骨质疏松症在T1的14.4%,T2的7.3%和T3.7的5.7%被诊断为骨质疏松症.
- 每天UCr增加1g与骨质疏松症的几率比率为0.37有关,这表明它具有保护作用.
结论:
- 低24小时尿液肌素,低肌肉质量的指标,与低骨矿物质密度显著相关.
- 低肌肉质量是韩国预透析CKD患者骨质疏松症的独立风险因素.
- 需要进一步的研究来证实肌肉质量对CKD患者骨健康的影响.
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