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异质增强剂状态调节β细胞对代谢压力的反应

Liu Wang1, Jie Wu1, Madeline Sramek1

  • 1Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Scottsdale, AZ, USA.

Nature communications
|October 30, 2024
PubMed
概括

肥胖会损害胰腺β细胞,导致2型糖尿病. 这项研究揭示了单个β细胞的表观遗传变化,特别是增强器动力学如何导致这种功能障碍,并确定了保护性神经生长因子信号传递.

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