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Updated: Jun 9, 2025

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
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Published on: February 10, 2012

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尼古丁诱导的CHRNA5激活调节CES1的表达,影响头部和部状细胞癌的复发和通过MEK/ERK途径转移

Chen Feng1,2, Wei Mao1, Chenyang Yuan3

  • 1Department of Otolaryngology, Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cell death & disease
|October 30, 2024
PubMed
概括

尼古丁通过激活CHRNA5,通过MEK/ERK通路调节CES1,促进头癌 (HNSC) 的生长和扩散. 减少CHRNA5可以抑制这些效应,但尼古丁可以逆转这些效应.

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