感染Mycobacterium结核病巨细胞的全基因组查揭示了GID/CTLH复杂介导的细菌生长调节

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Nelson V Simwela1, Luana Johnston1, Paulina Pavinski Bitar2

  • 1Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Nature communications
|October 30, 2024
PubMed
概括

葡萄糖诱导降解/C-终端到LisH (GID/CTLH) 复合物抑制宿主对抗像Mycobacterium tuberculosis这样的细菌的防御能力. 它的缺失增强了巨细胞的抗微生物活性,限制了细菌的生长.

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