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在NHANES 2005-2018研究中探索缺乏症和慢性阻塞性肺病之间的关联

Yixin Zhao¹, Hongwei Li¹, Zhenyu Wang²

¹The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.

Scientific reports

|October 30, 2024

概括

耗尽会增加慢性阻塞性肺病 (COPD) 的风险,中性粒细胞和SII等炎症标志物起着关键作用. 解决水平可能有助于预防和管理COPD.

科学领域:

肺部医学肺部医学
营养科学营养科学
流行病学流行病学

背景情况:

慢性阻塞性肺病 (COPD) 构成了全球严重的健康负担.
对于肺功能至关重要,可能会影响呼吸系统的健康.
系统性炎症与COPD的发病有关.

研究的目的:

调查耗得分 (MDS) 和COPD之间的关联.
探索炎症标志物在MDS-COPD关系中的调解作用.

主要方法:

对来自NHANES (2005-2018) 的30490名参与者的横截面分析.
基于利尿剂使用,PPI,功能和酒精消耗的MDS计算.
使用中性粒细胞,血清白蛋白和SII的物流回归和调解分析.

主要成果:

在单变量和多变量分析中,较高的MDS显著与COPD风险增加有关.
中性粒细胞水平和SII与慢性肺炎有积极的关联,而血清白蛋白与慢性肺炎有反向的关联.
中性粒细胞,血清白蛋白和SII显著介导了MDS和COPD之间的关系.

结论:

较高的耗评分是COPD的重要危险因素.
系统性炎症标志物调解耗和COPD之间的联系.
优化的状态可能为COPD预防和管理提供一种新的策略.

关键词:

慢性阻塞性肺病 (COPD) 1 慢性阻塞性肺病炎症3 炎症3 炎症3 耗耗评分 (MDS) 2耗耗评分 (MDS) 2耗评分 (MDS) 2耗评分 (MDS) 2耗评分 (MDS) 3耗评分 (MDS) 4耗评分 (MDS) 5耗评分 (MDS) 6耗评分 (MDS) 7耗评分 (MDS) 8耗评分 (MDS) 9耗评分 (MDS) 9耗评分 (MDS) 9耗评分 (MDS) 9耗评分 (MDS) 9耗评分 (MDS) 9耗评分 (MDS)尼恩斯5 尼恩斯5 公共卫生战略4

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